Intralesional cidofovir for recurrent respiratory papillomatosis in children.
| Autor: | Pransky SM; Pediatric Otolaryngology, Children's Hospital and Health Center, San Diego, Calif 92123, USA., Magit AE, Kearns DB, Kang DR, Duncan NO |
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| Jazyk: | angličtina |
| Zdroj: | Archives of otolaryngology--head & neck surgery [Arch Otolaryngol Head Neck Surg] 1999 Oct; Vol. 125 (10), pp. 1143-8. |
| DOI: | 10.1001/archotol.125.10.1143 |
| Abstrakt: | Objective: To assess the potential benefit of intralesional administration of cidofovir, an acyclic nucleoside phosphonate with activity against several DNA viruses, for treating severe respiratory papillomas in pediatric patients. Design: Prospective case series. Setting: Tertiary care children's hospitals. Patients: Five pediatric patients with severe recurrent respiratory papillomatosis requiring laryngoscopy with carbon dioxide laser therapy more frequently than once a month to maintain airway patency. Each patient underwent between 12 and 33 laryngoscopies with laser treatment prior to being injected with cidofovir. Intervention: Microsuspension laryngoscopy with intralesional injection of cidofovir (Vistide) in conjunction with mechanical debulking and carbon dioxide laser of papillomas. Main Outcome Measure: Papilloma stage at time of serial laryngoscopies. Results: One patient was disease free and 3 patients demonstrated a dramatic response to adjuvant therapy with cidofovir at the 9-month follow-up visit after the last injection of cidofovir. One patient showed an improvement in papilloma stage that was possibly related to concurrent therapy with interferon. Conclusions: Intralesional injection of cidofovir seems to be of benefit in the treatment of severe respiratory papillomatosis in pediatric patients. Larger prospective studies with longer follow-up will be required before cidofovir can be considered an accepted means of managing this difficult disease. |
| Databáze: | MEDLINE |
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