| Autor: |
Herrera-Garza J; Department of Haematology, Dr José E González University Hospital and School of Medicine, Autonomous University of Nuevo León, Monterrey, México., Jaime-Pérez J, Montemayor J, Ibarra-Peart R, Gómez-Almaguer D |
| Jazyk: |
angličtina |
| Zdroj: |
Bone marrow transplantation [Bone Marrow Transplant] 1999 Oct; Vol. 24 (8), pp. 845-8. |
| DOI: |
10.1038/sj.bmt.1701986 |
| Abstrakt: |
Four multitransfused patients with severe aplastic anaemia (SAA) are described. Two received a BMT after conditioning with cyclophosphamide (Cy) plus antithymocyte globulin (ATG). Both suffered a graft failure (GF) and had a second transplant with PBSC from the original donor. Two other patients received a PBSCT as a first option, with Cy as the only conditioning drug. The four patients received methotrexate (MTX) and cyclosporine (CYA) as post-grafting immunosuppression. The two BMT patients with GF were successfully rescued with a PBSC second transplant. In the two cases where a PBSCT was done as a first option no GF was observed and a successful and complete haematological recovery was achieved. In conclusion, PBSCT rescued two SAA patients with GF after BMT. PBSCT without ATG as a first option produced a quick and complete haematological recovery in two additional patients, suggesting that PBSCT without ATG can be an alternative to BMT plus ATG in SAA as a first transplant option. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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