Autor: |
Gebhard DH; Department of Microbiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA., Dow JL, Childers TA, Alvelo JI, Tompkins MB, Tompkins WA |
Jazyk: |
angličtina |
Zdroj: |
The Journal of infectious diseases [J Infect Dis] 1999 Nov; Vol. 180 (5), pp. 1503-13. |
DOI: |
10.1086/315089 |
Abstrakt: |
The acute stage of feline immunodeficiency virus (FIV) infection is characterized by the appearance of a major CD8 subpopulation with reduced expression of the CD8 beta chain (CD8alpha+betalo). CD8 antiviral activity was subsequently shown to be mediated by the CD8alpha+betalo phenotype, which is the dominant CD8 phenotype in long-term infected cats. Two- and three-color flow cytometric analysis demonstrated that the CD8alpha+betalo subset is L-selectin negative (CD62L-) and has increased expression of CD44, CD49d, and CD18, consistent with an activation phenotype. The CD8alpha+betaloCD62L- cells but not the CD8alpha+betahiCD62L+ cells demonstrated strong antiviral activity in the FIV acute-infection assay. The progressive expansion of the CD8alpha+betaloCD62L- effector subset cells in FIV-infected cats parallels that seen in human immunodeficiency virus (HIV)-infected patients, suggesting that failure in homeostatic mechanisms regulating lymphocyte activation or trafficking (or both) may be a consequence of both HIV and FIV infections. |
Databáze: |
MEDLINE |
Externí odkaz: |
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