| Autor: |
Onufriev MV; Institute of Higher Nervous Activity and Neurophysiology, Russian Acad. Sci., Moscow, Russia., Stepanichev MIu, Mitrokhina OS, Moiseeva IuV, Lazareva NA, Guliaeva NV |
| Jazyk: |
ruština |
| Zdroj: |
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 1999 Apr; Vol. 85 (4), pp. 531-8. |
| Abstrakt: |
Within 8 days of a 10-min cardiac arrest, accumulation of material reacting with 2-thiobarbituric acid was revealed in the hippocampus (74%) and cerebellum (47%) of male Wistar rats. Oxidative stress was accompanied by a twofold decrease of the nitric oxide synthase activity in the brain tissue. In vitro experiments showed a dose-dependent decrease of nitric oxide synthase activity in the brain homogenates as a result of the oxidative stress induced by hydrogen peroxide or sodium hypochlorite. The findings suggest that the oxidative stress may decrease nitric oxide synthase activity as a result of direct effects of the active oxygen on the enzyme. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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