[The effect of polikatan on the ototoxic action of kanamycin].

Autor: Spasov AA; Volgograd State Medical Academy, Russia., Lobzov MS, Sanzharovskaia NK, Kozhevnikova EV, Kuzubova EA
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1999 Jul-Aug; Vol. 62 (4), pp. 65-6.
Abstrakt: Experiments on guinea pigs demonstrated that preliminary injection of polycatan (standardized magnesium solution containing the mineral bischofite) into the parotid region by means of electrophoresis reduces the ototoxic effect of the aminoglycoside antibiotic kanamycin. Polycatan prevents kanamycin-induced degenerative changes of the hair cells found in the labyrinth of the internal ear and improves the local blood flow.
Databáze: MEDLINE
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