Quantitative MR diffusion mapping and cyclosporine-induced neurotoxicity.

Autor: Coley SC; Department of Neuroradiology, University College London Medical School, England., Porter DA, Calamante F, Chong WK, Connelly A
Jazyk: angličtina
Zdroj: AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 1999 Sep; Vol. 20 (8), pp. 1507-10.
Abstrakt: Apparent diffusion coefficient maps of two patients with cyclosporine-induced neurotoxicity showed areas of increased diffusion that corresponded to the characteristic regions of signal change on routine T2-weighted sequences. The majority of lesions subsequently resolved without residual T2 or diffusion signal alteration. These findings suggest that, in our patients, the neurotoxic effects of cyclosporine resulted in a partially reversible extravasation of fluid into the cerebral interstitium and were not associated with acute ischemia.
Databáze: MEDLINE