Combinatorial search of substituted beta-cyclodextrins for phosphatase-like activity.

Autor: Yu J; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The University of Illinois at Chicago, 60612, USA., Zhao Y, Holterman MJ, Venton DL
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Sep 20; Vol. 9 (18), pp. 2705-10.
DOI: 10.1016/s0960-894x(99)00468-0
Abstrakt: Thirteen per-6-akylamino-6-deoxy-beta-cyclodextrin libraries (beta-CD libraries) were generated by a solution-phase combinatorial synthesis starting from per-6-iodo-6-deoxy-beta-CD and different combinations of eleven individual amine nucleophiles. Certain libraries showed the ability to hydrolyzep-nitrophenyl phosphate in the presence of Zn2+.
Databáze: MEDLINE