Dopamine and noradrenaline release in the prefrontal cortex of rats during classical aversive and appetitive conditioning to a contextual stimulus: interference by novelty effects.

Autor: Feenstra MG; Netherlands Institute for Brain Research, Graduate School Neurosciences, Amsterdam. m.feenstra@nih.knaw.nl, Teske G, Botterblom MH, De Bruin JP
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 1999 Sep 17; Vol. 272 (3), pp. 179-82.
DOI: 10.1016/s0304-3940(99)00601-1
Abstrakt: Extracellular dopamine and noradrenaline concentrations in the medial prefrontal cortex were determined using online microdialysis in freely moving rats during classical appetitive or aversive conditioning to a contextual conditioned stimulus (CS). As CS we used placement in a Skinner box where either foot shocks or food pellets were delivered as unconditioned stimuli. In the aversive conditioning group we observed a conditioned increase in noradrenaline, but not in dopamine release, upon a final exposure to CS-alone. Other conditioned effects were possibly masked by the continued presence of novelty and handling effects of the transfer to the Skinner box.
Databáze: MEDLINE
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