| Autor: |
Escribano J; Sección de Biotecnología IDR, Universidad de Castilla-La Mancha, Albacete, Spain., Díaz-Guerra MJ, Riese HH, Ontañón J, García-Olmo D, García-Olmo DC, Rubio A, Fernández JA |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 1999 Sep 20; Vol. 144 (1), pp. 107-14. |
| DOI: |
10.1016/s0304-3835(99)00211-6 |
| Abstrakt: |
Saffron corms contain a proteoglycan that is highly cytotoxic on human tumor cells. The present work was undertaken to study the possible immunomodulatory and anti-invasive properties of this compound. Non-cytotoxic concentrations of this glycoconjugate promoted significant macrophage activation, detected by the release of nitric oxide. A rapid activation of protein kinase C and NF-kappaB was obtained after proteoglycan treatment, which could explain the induction of nitric oxide synthase. Proteoglycan concentrations ranging from 10-1000 ng/ml specifically promoted apoptosis of macrophages, probably triggered by their activation. This molecule did not inhibit in vitro migration or invasion of human tumor cells. Altogether these results support a plausible immuno-modulating activity for this saffron Crocus compound. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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