| Autor: |
Lowe JA 3rd; Central Research Division, Pfizer Inc. Groton, CT 06340, USA., Qian W, Volkmann RA, Heck S, Nowakowski J, Nelson R, Nolan C, Liston D, Ward K, Zorn S, Johnson C, Vanase M, Faraci WS, Verdries KA, Baxter J, Doran S, Sanders M, Ashton M, Whittle P, Stefaniak M |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Sep 06; Vol. 9 (17), pp. 2569-72. |
| DOI: |
10.1016/s0960-894x(99)00432-1 |
| Abstrakt: |
The synthesis and SAR of a series of 6-(4-(substituted)phenyl)-2-aminopyridines as inhibitors of nitric oxide synthase are described. Compound 3a from this series shows potent and selective inhibition of the human nNOS isoform, with pharmacokinetics sufficient to provide in vivo inhibition of nNOS activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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