Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists.

Autor: Ryder TR; Department of Chemistry, Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105, USA., Hu LY, Rafferty MF, Lotarski SM, Rock DM, Stoehr SJ, Taylor CP, Weber ML, Miljanich GP, Millerman E, Szoke BG
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Aug 16; Vol. 9 (16), pp. 2453-8.
DOI: 10.1016/s0960-894x(99)00405-9
Abstrakt: Selective N-Type Voltage Sensitive Calcium Channel (VSCC) antagonists have shown utility in several models of pain and ischemia. We report the structure-activity relationship at the proximal phenyl group in a series of non-peptidyl VSCC blockers.
Databáze: MEDLINE