RADHA--a new male germ line-specific chromosomal protein of Drosophila.

Autor: Harhangi HR; Department of Physiological Chemistry and Pathobiochemistry, Johannes-Gutenberg University, Duesbergweg 6, D-55099 Mainz, Germany., Sun X, Wang YX, Akhmanova A, Miedema K, Heyting C, Hennig W
Jazyk: angličtina
Zdroj: Chromosoma [Chromosoma] 1999 Aug; Vol. 108 (4), pp. 235-42.
DOI: 10.1007/s004120050373
Abstrakt: A new chromosomal protein - RADHA - of Drosophila is described that is specific for the male germ line. It is encoded by a single-copy gene, located in the region 96C-D of D. melanogaster polytene chromosomes. Transcription of the radha gene is restricted to the primary spermatocyte stage. The protein initially accumulates in some of the Y-chromosomal lampbrush loops. After meiosis it is found in the nuclei of spermatids and might be involved in chromatin rearrangement processes in the male germ line. RADHA is a basic protein with a C-terminal leucine zipper region and several segments capable of forming coiled-coil structures.
Databáze: MEDLINE