MRI appearances of metachromatic leukodystrophy.

Autor: Faerber EN; Department of Radiology, St. Christopher's Hospital for Children, MCP. Hahnemann School of Medicine, Erie Avenue and Front Street, Philadelphia, PA 19134-1095, USA., Melvin J, Smergel EM
Jazyk: angličtina
Zdroj: Pediatric radiology [Pediatr Radiol] 1999 Sep; Vol. 29 (9), pp. 669-72.
DOI: 10.1007/s002470050672
Abstrakt: Background: The leukodystrophies constitute a wide spectrum of cerebral disorders of varying etiology. The imaging appearances on CT and MRI are recognizable as abnormalities of white matter; however, it may be impossible to arrive at the correct diagnosis based on imaging studies alone.
Patients and Methods: Three patients of varying age and clinical symptomatology diagnosed with metachromatic leukodystrophy (MLD) had remarkably similar MRI appearances. A "tigroid" or "leopard-skin" appearance was demonstrated within deep white matter in each case.
Results: All of the patients had biochemical confirmation of MLD.
Conclusion: Although the "tigroid" pattern previously was considered to be pathognomonic of Pelizaeus-Merzbacher disease, the diagnosis of MLD must now be considered when these MRI appearances are encountered.
Databáze: MEDLINE
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