The synergistic action of ethanol and nerve growth factor in the induction of neuronal nitric oxide synthase.

Autor: Phung YT; Department of Pediatrics, University of California at San Francisco, 94143-0106, USA., Black SM
Jazyk: angličtina
Zdroj: Alcohol and alcoholism (Oxford, Oxfordshire) [Alcohol Alcohol] 1999 Jul-Aug; Vol. 34 (4), pp. 506-10.
DOI: 10.1093/alcalc/34.4.506
Abstrakt: Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.
Databáze: MEDLINE