| Autor: |
Node K; Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, LMRC-322, Boston, MA 02115, USA., Huo Y, Ruan X, Yang B, Spiecker M, Ley K, Zeldin DC, Liao JK |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 1999 Aug 20; Vol. 285 (5431), pp. 1276-9. |
| DOI: |
10.1126/science.285.5431.1276 |
| Abstrakt: |
The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. The cytochrome P450 isoform CYP2J2 was cloned and identified as a potential source of EETs in human endothelial cells. Physiological concentrations of EETs or overexpression of CYP2J2 decreased cytokine-induced endothelial cell adhesion molecule expression, and EETs prevented leukocyte adhesion to the vascular wall by a mechanism involving inhibition of transcription factor NF-kappaB and IkappaB kinase. The inhibitory effects of EETs were independent of their membrane-hyperpolarizing effects, suggesting that these molecules play an important nonvasodilatory role in vascular inflammation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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