| Autor: |
Aviles DH; Department of Pediatrics, Louisiana State University Medical Center and Children's Hospital, New Orleans 70118, USA., Irwin KC, Dublin LS, Vehaskari VM |
| Jazyk: |
angličtina |
| Zdroj: |
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 1999 May; Vol. 13 (4), pp. 298-300. |
| DOI: |
10.1007/s004670050612 |
| Abstrakt: |
When focal segmental glomerulosclerosis (FSGS) has reached the stage of chronic renal insufficiency, further progression is usually considered inevitable. African-American patients are believed to exhibit a particularly aggressive form of FSGS. We have treated five African-American patients, aged 11-18 years, with FSGS and reduced renal function using intensive intravenous methylprednisolone protocol, combined with chlorambucil in three cases. All patients had a pretreatment creatinine clearance of less than 50 ml/min per 1.73 m2. Three patients responded with normalization of creatinine clearance and serum albumin levels and had no or only minimal proteinuria at latest follow-up. One patient showed no improvement and one patient progressed to end-stage renal disease. These findings indicate, for the first time, that even severe FSGS may respond to aggressive methylprednisolone with or without alkylating agent treatment, and that African-American race does not preclude a favorable response. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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