Tetrapeptide derived inhibitors of complexation of a class II MHC: the peptide backbone is not inviolate.

Autor:	Jones AB; Department of Basic Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA., Acton JJ 3rd, Rivetna MN, Cummings RT, Cubbon RM, Nichols EA, Schwartz CD, Wicker LS, Hermes JD
Jazyk:	angličtina
Zdroj:	Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Jul 19; Vol. 9 (14), pp. 2109-14.
DOI:	10.1016/s0960-894x(99)00333-9
Abstrakt:	Major histocompatabilty (MHC) proteins rely heavily on peptide backbone recognition for ligation. Nonetheless, modifications to the polyamide backbone of a tetrapeptide ligand can be made without abrogating binding.
Databáze:	MEDLINE
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