| Autor: |
Ciccarone TM; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA., MacTough SC, Williams TM, Dinsmore CJ, O'Neill TJ, Shah D, Culberson JC, Koblan KS, Kohl NE, Gibbs JB, Oliff AI, Graham SL, Hartman GD |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Jul 19; Vol. 9 (14), pp. 1991-6. |
| DOI: |
10.1016/s0960-894x(99)00323-6 |
| Abstrakt: |
The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Substitutions on an imidazolylmethyl-AMBA-methionine template gave a highly potent and cell-active inhibitor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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