| Autor: |
Anderson BA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Harn NK, Hansen MM, Harkness AR, Lodge D, Leander JD |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Jul 19; Vol. 9 (14), pp. 1953-6. |
| DOI: |
10.1016/s0960-894x(99)00315-7 |
| Abstrakt: |
A novel series of 3-aryl-5H-2,3-benzodiazepines with N-3 aromatic substituents has been synthesized. Good in vivo anticonvulsant activity of the new compounds has been demonstrated employing the maximal electroshock seizure test in mice. Evaluation of a subset of the compounds in the cortical wedge assay confirmed the new structures to be AMPA antagonists. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect