| Autor: |
Jin Y; Department of Zoology and Genetics, Iowa State University, Ames 50011, USA., Wang Y, Walker DL, Dong H, Conley C, Johansen J, Johansen KM |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular cell [Mol Cell] 1999 Jul; Vol. 4 (1), pp. 129-35. |
| DOI: |
10.1016/s1097-2765(00)80195-1 |
| Abstrakt: |
We have cloned and characterized JIL-1, a novel tandem kinase in Drosophila that associates with the chromosomes throughout the cell cycle. Antibody staining and live imaging of JIL-1-GFP transgenic flies show that JIL-1 localizes to the gene-rich interband regions of larval polytene chromosomes and is upregulated almost 2-fold on the hypertranscribed male X chromosome compared to autosomes. Phylogenetic analysis suggests that JIL-1 together with human MSKs defines a separate family of tandem kinases. That JIL-1 is a functional kinase was demonstrated by autophosphorylation and phosphorylation of histone H3 in vitro. Based on these findings, we propose that JIL-1 may play a role in transcriptional control potentially by regulating chromatin structure. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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