Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone.

Autor:	Seifer DB; Center for Reproduction, Endocrinology and Fertility, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08902, USA. seiferdb@umdnj.edu, Scott RT Jr, Bergh PA, Abrogast LK, Friedman CI, Mack CK, Danforth DR
Jazyk:	angličtina
Zdroj:	Fertility and sterility [Fertil Steril] 1999 Jul; Vol. 72 (1), pp. 63-5.
DOI:	10.1016/s0015-0282(99)00193-4
Abstrakt:	Objective: To test the hypothesis that women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B levels before a rise in day 3 serum FSH levels. Design: Case-control study. Setting: Tertiary care fertility center. Patient(s): One hundred nine women with nonovarian infertility (tubal factor or male factor) and 47 women with declining ovarian reserve who underwent assisted reproductive techniques. Intervention(s): None. Main Outcome Measure(s): Serum inhibin B and FSH levels, number of ampules of gonadotropins administered, E2 levels on the day of hCG administration, number of oocytes retrieved, clinical pregnancy rate, and cycle cancellation rate. Result(s): Women who had declining ovarian reserve as demonstrated by an increased gonadotropin requirement, a decreased E2 response, fewer retrieved oocytes, a lower clinical pregnancy rate, and a higher cycle cancellation rate had lower day 3 serum inhibin B levels despite having nonelevated day 3 FSH levels similar to those of women with nonovarian infertility. Conclusion(s): Women with declining ovarian responsiveness and clinical outcomes consistent with declining ovarian reserve had decreased day 3 serum inhibin B levels despite having nonelevated day 3 serum FSH concentrations. Declining ovarian reserve may be demonstrated by a decrease in day 3 inhibin B levels before a rise in day 3 FSH levels.
Databáze:	MEDLINE
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