Synthesis and identification of conformationally constrained selective MMP inhibitors.

Autor: Freskos JN; Department of Medicinal Chemistry, Searle Discovery Research, St Louis, MO 63198, USA., McDonald JJ, Mischke BV, Mullins PB, Shieh HS, Stegeman RA, Stevens AM
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Jul 05; Vol. 9 (13), pp. 1757-60.
DOI: 10.1016/s0960-894x(99)00285-1
Abstrakt: We have discovered a new series of potent conformationally constrained MMP Inhibitors that are selective for MMP-13 over MMP-1.
Databáze: MEDLINE