Micellar catalysis for oxidation of nitric oxide (NO) in the multi-phase systems in vivo.

0 could not be used in order to calculate the efficiency of catalysis from the experimental data. It was shown that, unlike in two-phase systems (with an aqueous and a hydrophobic phase), the dependence of H on Q in multi-phase systems, that include all in vivo systems, is different. The multiple phase state of the systems has a determining role for a regulation of NO-dependent processes and in the realization of conditions of 'NO catastrophes'. -->
Substance Nomenclature: 0 (Lipids)
0 (Micelles)
059QF0KO0R (Water)
31C4KY9ESH (Nitric Oxide)
Entry Date(s): Date Created: 19990714 Date Completed: 19990802 Latest Revision: 20190621
Update Code: 20240829
DOI: 10.1016/s0014-5793(99)00578-5
PMID: 10403409
Autor: Beda NV; Institute of Molecular Genetics, RAS, Moscow, Russia., Suntsova TP
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 1999 Jun 18; Vol. 453 (1-2), pp. 229-35.
DOI: 10.1016/s0014-5793(99)00578-5
Abstrakt: The equation of the dependence of the third-order reaction acceleration due to concentrating the reagents in a small volume of the hydrophobic phase on the partition coefficients of reagents (Q) and on the lipophilic phase fraction (x), [k(app)/ k2 = H(Q(NO),Q(O2),x)] was analyzed. It was demonstrated that the numeric value of dH/dx at x-->0 could not be used in order to calculate the efficiency of catalysis from the experimental data. It was shown that, unlike in two-phase systems (with an aqueous and a hydrophobic phase), the dependence of H on Q in multi-phase systems, that include all in vivo systems, is different. The multiple phase state of the systems has a determining role for a regulation of NO-dependent processes and in the realization of conditions of 'NO catastrophes'.
Databáze: MEDLINE
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