| Autor: |
Patron RL; Department of Internal Medicine, Medical College of Virginia Campus of Virginia Commonwealth University, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond 23249, USA., Climo MW, Goldstein BP, Archer GL |
| Jazyk: |
angličtina |
| Zdroj: |
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1999 Jul; Vol. 43 (7), pp. 1754-5. |
| DOI: |
10.1128/AAC.43.7.1754 |
| Abstrakt: |
The rabbit model of endocarditis was used to test the effectiveness of vancomycin and two different lysostaphin dosing regimens for the treatment of infections caused by a Staphylococcus aureus strain with reduced susceptibility to vancomycin (glycopeptide-intermediate susceptible S. aureus [GISA]). Vancomycin was ineffective, with no evidence of sterilization of aortic valve vegetations. However, rates of sterilization of aortic valve vegetations were significantly better for animals treated with either a single dose of lysostaphin (43%) or lysostaphin given twice daily for 3 days (83%) than for animals treated with vancomycin. Rabbits given a single dose of lysostaphin followed by a 3-day drug-free period had mean reductions in aortic valve vegetation bacterial counts of 7.27 and 6.63 log10 CFU/g compared with those for untreated control rabbits and the vancomycin-treated group, respectively. We conclude that lysostaphin is an effective alternative for the treatment of experimental aortic valve endocarditis caused by a clinical VISA strain. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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