Estrogen therapy for depression in postmenopausal women.

Autor: Carranza-Lira S; Gynecologic Endocrinology Service, Hospital de Gineco-Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, Mexico City, Mexico. scarranzal@mexis.com, Valentino-Figueroa ML
Jazyk: angličtina
Zdroj: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 1999 Apr; Vol. 65 (1), pp. 35-8.
DOI: 10.1016/s0020-7292(99)00017-x
Abstrakt: Objective: To look at the modification in depressive mood in postmenopausal depressed women after estrogen replacement therapy (ERT).
Method: Twelve depressed patients divided into two groups of six women each were studied. One group received conjugated equine estrogens (CEE) 0.625 mg/day; the other did not receive any treatment (control group). Mood was assessed in all the subjects at baseline and at 6 months with Hamilton Rating Scale score and considered as depression when it was > 15. Differences between groups were determined by Mann-Whitney U-test, and in each group between baseline and 6-month values with Wilcoxon test.
Results: The ERT group had a statistically significant decrease in depressive mood (21 vs. 13 points, P < 0.03), while in the control group no significant change was found. Final Hamilton scale scores were significantly lower (P < 0.05) in those under ERT, when compared with those in the control group.
Conclusion: Depressive mood decreased after 6 months with CEE, so the prescription of ERT can be useful in postmenopausal women with depressive mood.
Databáze: MEDLINE
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