| Autor: |
Card JW; Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada., Leeder RG, Racz WJ, Brien JF, Bray TM, Massey TE |
| Jazyk: |
angličtina |
| Zdroj: |
Toxicology [Toxicology] 1999 Apr 15; Vol. 133 (2-3), pp. 75-84. |
| DOI: |
10.1016/s0300-483x(99)00009-8 |
| Abstrakt: |
Amiodarone (AM) is a potent antidysrhythmic agent that is limited in clinical use by its adverse effects, including potentially life-threatening AM-induced pulmonary toxicity (AIPT). The present study tested the ability of dietary supplementation with vitamin E (500 IU d,1-alpha-tocopherol acetate/kg chow) to protect against pulmonary damage following intratracheal administration of AM (1.83 micromol) to the male golden Syrian hamster. At 21 days post-dosing, animals treated with AM had increased lung hydroxyproline content and histological disease index values compared to control (P < 0.05), which were indicative of fibrosis. Dietary vitamin E supplementation for 6 weeks resulted in a 234% increase in lung vitamin E content at the time of AM dosing, and maintenance on the diet prevented AM-induced elevation of hydroxyproline content and disease index 21 days post-dosing. Dietary vitamin E supplementation also decreased hydroxyproline content and disease index values in hamsters treated intratracheally with distilled water, the AM vehicle. These results demonstrate a protective role for vitamin E in an in vivo model of AIPT, and suggest that this antioxidant may have non-specific antifibrotic effects in the lung. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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