| Autor: |
Freebern WJ; Department of Microbiology, and Center for Microbial Pathogenesis, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14214, USA., Niles EG, LoVerde PT |
| Jazyk: |
angličtina |
| Zdroj: |
Gene [Gene] 1999 Jun 11; Vol. 233 (1-2), pp. 33-8. |
| DOI: |
10.1016/s0378-1119(99)00161-4 |
| Abstrakt: |
A cDNA encoding a second full-length member of the Schistosoma mansoni RXR family (SmRXR-2) was identified. The nucleotide sequence of SmRXR-2 translates into a protein of 784 amino acids with a pI of 7.63 and an approximate mass of 78kDa making it the largest reported RXR to date. Phylogenetic tree analysis provides evidence that SmRXR-2 is the most ancient full-length RXR identified. SmRXR-2 exhibits unique sequence features compared with other RXRs. RT-PCR results demonstrate that the SmRXR-2 gene is constitutively expressed and thus must play multiple roles throughout schistosome development in the vertebrate host. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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