| Autor: |
Milner BJ; Department of Medicine and Therapeutics (Medical Genetics), Aberdeen University Medical School, Foresterhill, Aberdeen AB25 2ZD, UK., Brown I, Gabra H, Kitchener HC, Parkin DE, Haites NE |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of oncology [Int J Oncol] 1999 Jul; Vol. 15 (1), pp. 117-9. |
| DOI: |
10.3892/ijo.15.1.117 |
| Abstrakt: |
The objective of this study was to compare the frequency of two common p21WAF1/Cip1 gene polymorphisms in ovarian cancer patients with that in age-matched controls, from a population originating from Eastern Scotland. Both polymorphisms were found significantly less frequently in both the constitutive and tumour tissue DNA of ovarian cancer patients (3/65; 4.6%), than in that from geographically and age-matched controls (25/186; 13.4%) (p=0.0495, chi2). Furthermore, we found no p21WAF1/Cip1 gene mutations in any of the tumours, reflected by a relatively low degree of loss of heterozygosity (LOH) at the chromosomal region where the gene maps, providing further evidence that the p21WAF1/Cip1 gene is not mutated in ovarian cancer. The data suggest however, that there may potentially be a protective function for the two p21WAF1/Cip1 gene polymorphisms in the population under study. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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