Hemispheric asymmetry in depression and mania. A longitudinal QEEG study in bipolar disorder.

Autor: Koek RJ; Psychiatry Service, Sepulveda VA Medical Center, CA 91343, USA. rkoekmd@pol.net, Yerevanian BI, Tachiki KH, Smith JC, Alcock J, Kopelowicz A
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 1999 May; Vol. 53 (2), pp. 109-22.
DOI: 10.1016/s0165-0327(98)00171-2
Abstrakt: Background: previous research has been inconclusive about the nature of hemispheric asymmetry in emotional processing.
Method: 13 patients with DSM-IV bipolar disorder received repeated QEEGs over 2 years in different mood states. Z-score measures of asymmetry were assessed.
Results: asymmetry in frontotemporal slow-wave activity appeared to be in opposite directions in depression compared to mania/hypomania.
Conclusions: mood change in bipolar disorder is associated with change in QEEG asymmetry.
Limitations: study of larger numbers of more homogenous patients under similar conditions is needed.
Clinical Relevance: study of mood state-dependent asymmetry changes in bipolar disorder may lead to better understanding of hemispheric processing of emotion.
Databáze: MEDLINE
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