[Importance of estimated value of T-cell activation in insulin-dependent diabetes mellitus].
| Autor: | Zhuk EA, Galenok VA |
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| Jazyk: | ruština |
| Zdroj: | Terapevticheskii arkhiv [Ter Arkh] 1999; Vol. 71 (4), pp. 55-7. |
| Abstrakt: | Aim: To determine the role of estimated value HLA-DR+/CD19+ in patients with insulin-dependent diabetes mellitus (IDDM) in the course of the disease. Materials and Methods: The number of CD+ and HLA-DR+ lymphocytes and the ratio HLA-DR+/ CD19+ were estimated in the peripheral blood of 70 IDDM patients aged 9-47 years with the disease duration since the diagnosis 0-10. Indirect immunofluorescence with monoclonal antibodies was employed. Results: The index HLA-DR+/CD19+ was normal in newly-diagnosed IDDM patients and tended to an increase with the disease aggravation. Conclusion: The index HLA-DR+/CD19+ can be used as an additional marker of T-lymphocyte activation, as a criterium of unfavorable IDDM course. |
| Databáze: | MEDLINE |
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