| Autor: |
Meléndez-Alafort L; Instituto Nacional de Nutrición, Salvador Zubirán, Mexico., Ferro-Flores G, Arteaga-Murphy C, Pedraza-López M, González-Zavala MA, Tendilla JI, García-Salinas L |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of pharmaceutics [Int J Pharm] 1999 May 25; Vol. 182 (2), pp. 165-72. |
| DOI: |
10.1016/s0378-5173(99)00054-x |
| Abstrakt: |
A direct labeling technique via EHDP for the preparation of 188Re-somatostatin analogue peptide beta-(2-naphthyl)-D-Ala-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-amide complex was developed. The influence of reaction conditions such as pH, temperature, weak ligand concentration and stannous chloride concentration were investigated. Methods of analysis were also established permitting identification of radiochemical impurities which may be present in the radiopharmaceutical solution. Results showed that under the procedure reported herein 188Re-peptide complex can be prepared with a radiochemical purity of 90% and a specific activity up to 1.8 GBq mg-1 without radiolytic degradation of the product. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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