[The immunomodulator ximedon lowers the level of induced DNA damages in bone marrow and peripheral blood cells: the possibilities for immunogenetic correction].

Autor: Cherepnev GV; Research Department, Republican Medical Diagnostic Center, Kazan, Russia., Tereshchenko VIu, Malyshev KV, Semenov VV, Slabnov IuD, Garaev RS
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1999 Mar-Apr; Vol. 62 (2), pp. 31-5.
Abstrakt: It was established in experiments on albino unbred mice and during treatment of patients with osteomyelitis that 30 mg/kg of ximidon suppresses the formation of micronuclear polychromatophilic erythrocytes found in the bone marrow of mice and peripheral blood of patients with chronic osteomyelitis. The interrelationship of the results obtained with the modulating effect of ximidon on the mitochondrial, thiol, and adenylate cyclase-dependent mechanisms of cell regulation is discussed.
Databáze: MEDLINE