| Autor: |
Amelin AV; Valdman Institute of Pharmacology, St. Petersburg State Medical University, Russia., Ivanov VE, Usachev NI, Pushkarev AA |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1999 Mar-Apr; Vol. 62 (2), pp. 12-5. |
| Abstrakt: |
Intravenous administration of clofelin blocks transudation of 131I-albumin into the dura mater of rats in electrical stimulation of the trigeminal ganglion. Preliminary injection of the alpha-adrenoblocker yohimbine and the antagonist of serotonin receptors 5-NT1 mianserin completely removes the blocking effect of clofelin. Naloxon and the alpha 1-adrenoblocker prazosin had no effect on the degree of expression of albumin transudation and the clophelin effect. The role of the adrenergic system, the presynaptic alpha 2-adrenoceptors in particular, in functioning of the trigeminovascular system and the development of neurogenic inflammation in the dura mater is discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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