Effects of long-term hemofiltration on circulating mediators and superoxide production during continuous endotoxin administration.
| Autor: | Ishihara S; U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas 78234-5012, USA., Ward JA, Tasaki O, Brinkley WW, Seraile LG, Pruitt BA Jr, Mozingo DW |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of trauma [J Trauma] 1999 May; Vol. 46 (5), pp. 894-9. |
| DOI: | 10.1097/00005373-199905000-00020 |
| Abstrakt: | Background: The purpose of this study was to test whether continuous hemofiltration eliminates cytokines and eicosanoids, or stimulates granulocyte function. Methods: Nineteen pigs were divided into a control group (n = 7), a hemofiltration group (n = 7), and an extracorporeal circuit only group (n = 5). All animals received the same amount of intravenous endotoxin and resuscitation fluid. Zero-balanced hemofiltration was started 30 minutes after initiation of endotoxemia and continued throughout the experiment. Plasma endotoxin, tumor necrosis factor-alpha, eicosanoids, superoxide production, and other physiologic parameters were measured before challenge and at scheduled intervals thereafter. Results: Eicosanoids were filtered but plasma concentrations were not reduced. Tumor necrosis factor-alpha was not filtered or adsorbed. There were no significant differences between groups in any measured parameters. Conclusion: Continuous hemofiltration could not efficiently remove tumor necrosis factor-alpha or eicosanoids. Also, continuous hemofiltration did not stimulate production of the proinflammatory mediators measured, nor improve respiratory distress. |
| Databáze: | MEDLINE |
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