The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms.
| Autor: | Layton MA; Staffordshire Rheumatology Centre, Stoke-on-Trent, UK., Jones PW, Alldersea JE, Strange RC, Fryer AA, Dawes PT, Mattey DL |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Rheumatology (Oxford, England) [Rheumatology (Oxford)] 1999 Jan; Vol. 38 (1), pp. 43-7. |
| DOI: | 10.1093/rheumatology/38.1.43 |
| Abstrakt: | Objectives: To investigate whether the therapeutic response of rheumatoid arthritis (RA) patients to D-penicillamine is associated with polymorphisms in genes of the glutathione S-transferase (GST) supergene family. Methods: Disease activity in 81 patients with RA treated with D-penicillamine monotherapy was assessed using the Stoke Index, a validated index of disease activity, prior to treatment and at 6 months. GST typing was performed using a polymerase chain reaction-based approach and a logistic regression model was used to investigate any possible association between the therapeutic response to D-penicillamine and the GST genotype. Results: A poor therapeutic response was associated with the GSTM1 null genotype [odds ratio (OR) 3.94], and in particular with the GSTM1*0/GSTM3*A haplotype (OR 7.63). Conclusions: Our results suggest that GST polymorphisms may influence the response to D-penicillamine in RA, and that patients in possession of the GSTM1*0/GSTM3*A haplotype are significantly less likely to show a beneficial response to the drug. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|