Risk of cutaneous malignant melanoma in patients with nonfamilial atypical nevi from a pigmented lesions clinic.

Autor: Snels DG; Department of Dermatology, Leiden University Medical Center, TNO Prevention and Health, The Netherlands., Hille ET, Gruis NA, Bergman W
Jazyk: angličtina
Zdroj: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 1999 May; Vol. 40 (5 Pt 1), pp. 686-93.
DOI: 10.1016/s0190-9622(99)70564-5
Abstrakt: Background: Atypical nevi (AN) are regarded as a major risk factor for occurrence of malignant melanoma. Few studies report an increase in relative risk for melanoma in patients with nonfamilial AN.
Objective: We measured the risk of melanoma in 195 patients with nonfamilial AN.
Methods: In a retrospective follow-up study the number of newly diagnosed melanomas during follow-up were inventoried. Included patients were invited for skin screening and nevus count.
Results: On the basis of our calculations, the relative risk for invasive melanoma in patients with nonfamilial AN, including those patients with a history of melanoma, is 41. For individuals with AN without a previously diagnosed melanoma, the relative risk was 37. Multivariate analysis did not reveal a specific risk factor for the occurrence of melanoma (including number of AN) because of small numbers. Invasive melanomas occurred in persons having 1, 5, 12, and 172 AN, respectively.
Conclusion: An increased risk for invasive cutaneous malignant melanoma in patients with nonfamilial AN was established.
Databáze: MEDLINE
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