[Action of KCN on intact and refractory thrombocytes].

Autor: Lisovskaia IL, Volkova RI, Pozin EIa, Markosian RA
Jazyk: ruština
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1976 Aug; Vol. 82 (8), pp. 940-3.
Abstrakt: The effect of low KCN concentrations (5-10(4) M) on the ADP-induced aggregation of intact and refractory rabbit platelets was studied. KCN did not change the aggregation of the intact platelets, but stimulated that of the refractory platelets. The effect of the inhibitor stimulating the aggregation was not connected with the release of additional amounts of ADP. A different sensitivity of the aggregation capacity of the intact and refractory cells to the partial inhibition of metabolism was discussed in terms of the suggested earlier "calcium" model of autoregulation of platelet aggregation.
Databáze: MEDLINE