The discovery of T cell help for B cell antibody formation: a perspective from the 30th anniversary of this discovery.

Autor: Janeway CA Jr; Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA. charles.janeway@yale.edu
Jazyk: angličtina
Zdroj: Immunology and cell biology [Immunol Cell Biol] 1999 Apr; Vol. 77 (2), pp. 177-9.
DOI: 10.1046/j.1440-1711.1999.00814.x
Abstrakt: Thirty years ago, Miller and Mitchell described the bone-marrow origin of antibody-forming cells and the thymic origin of the help needed to activate the bone-marrow-derived antibody formation. Since then, there has been a continuous stream of discovery in Australia, from Zinkernagel and Doherty's description of MHC-restricted antigen recognition to Goodnow's dissection of the maturation and tolerization of antigen-specific B cells. All of these discoveries, and many more described in the text, contribute to the modern synthesis in immunology.
Databáze: MEDLINE