| Autor: |
Shchelkanov MY; Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow, 123098, Russia., Eremin VF, Sakhuriya IB, Burunova VV, Pavlova TV, Kornilaeva GV, Karamov EV |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 1999 Apr; Vol. 64 (4), pp. 431-6. |
| Abstrakt: |
Changes in dehydrogenase activity of some continuous cell lines were studied during the response to acute infection in vitro with HIV-1 variants having different biological features. Soon after infection, the dehydrogenase activity of infected cells increased, and this increase was greater and more prolonged with the HIV-1 r/h variant than with the HIV-1 s/l variant. Later stages showed decreased dehydrogenase activity of HIV-1-infected cells compared to the noninfected control; this is a manifestation of the cytodestructive effect of the virus. The changes increased monotonously (but not in direct proportion) with an increase in the infecting dose. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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