| Autor: |
Slakeski N; Biochemistry and Molecular Biology Unit, School of Dental Science, University of Melbourne, Melbourne, Victoria, Australia., Cleal SM, Bhogal PS, Reynolds EC |
| Jazyk: |
angličtina |
| Zdroj: |
Oral microbiology and immunology [Oral Microbiol Immunol] 1999 Apr; Vol. 14 (2), pp. 92-7. |
| DOI: |
10.1034/j.1399-302x.1999.140203.x |
| Abstrakt: |
Porphyromonas gingivalis extracellular arginine- and lysine-specific proteinases have been implicated as major virulence factors in the development of adult periodontitis. We have previously purified a 48-kDa lysine-specific cysteine proteinase, designated PrtK48, from a P. gingivalis W50 cell-associated multiprotein complex. PrtK48 was non-covalently associated with three sequence-related adhesins designated PrtK39, PrtK15 and PrtK44 in the multiprotein complex. In this study we cloned and characterized the gene, designated prtK, that encodes a polyprotein that is post-translationally processed to yield the Lys-specific proteinase PrtK48 and the three sequence-related adhesins PrtK39, PrtK15 and PrtK44. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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