| Autor: |
Elliott MA; Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA. mark@mail.mmrrcc.upenn.edu, Walter GA, Swift A, Vandenborne K, Schotland JC, Leigh JS |
| Jazyk: |
angličtina |
| Zdroj: |
Magnetic resonance in medicine [Magn Reson Med] 1999 Mar; Vol. 41 (3), pp. 450-5. |
| DOI: |
10.1002/(sici)1522-2594(199903)41:3<450::aid-mrm4>3.0.co;2-9 |
| Abstrakt: |
Principal component analysis (PCA) is a powerful method for quantitative analysis of nuclear magnetic resonance spectral data sets. It has the advantage of being model independent, making it well suited for the analysis of spectra with complicated or unknown line shapes. Previous applications of PCA have required that all spectra in a data set be in phase or have implemented iterative methods to analyze spectra that are not perfectly phased. However, improper phasing or imperfect convergence of the iterative methods has resulted in systematic errors in the estimation of peak areas with PCA. Presented here is a modified method of PCA, which utilizes complex singular value decomposition (SVD) to analyze spectral data sets with any amount of variation in spectral phase. The new method is shown to be completely insensitive to spectral phase. In the presence of noise, PCA with complex SVD yields a lower variation in the estimation of peak area than conventional PCA by a factor of approximately 2. The performance of the method is demonstrated with simulated data and in vivo 31P spectra from human skeletal muscle. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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