| Autor: |
Muñoz Bellido JL; Departamento de Microbiología, Hospital Universitario de Salamanca, Spain., Alonso Manzanares MA, Yagüe Guirao G, Gutiérrez Zufiaurre MN, Toldos MC, Segovia Hernández M, Garcia-Rodríguez JA |
| Jazyk: |
angličtina |
| Zdroj: |
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1999 Apr; Vol. 43 (4), pp. 966-8. |
| DOI: |
10.1128/AAC.43.4.966 |
| Abstrakt: |
The in vitro activities of 13 fluoroquinolones (FQs) were tested against 90 Staphylococcus aureus clinical isolates: 30 wild type for gyrA, gyrB, grlA and norA and 60 with mutations in these genes. Clinafloxacin (CI-960), sparfloxacin, and grepafloxacin were the most active FQs against wild-type isolates (MICs at which 90% of isolates were inhibited, 0.06 to 0.1 microgram/ml). Mutations in grlA did not affect the MICs of newer FQs. grlA-gyrA double mutations led to higher MICs for all the FQs tested. Efflux mechanisms affected the newer FQs to a much lesser extent than the less recently developed FQs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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