| Autor: |
Rodoni D; Department of Internal Medicine, Inselspital, Berne, Switzerland., Hänni F, Gerber CM, Cottagnoud M, Neftel K, Täuber MG, Cottagnoud P |
| Jazyk: |
angličtina |
| Zdroj: |
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1999 Apr; Vol. 43 (4), pp. 963-5. |
| DOI: |
10.1128/AAC.43.4.963 |
| Abstrakt: |
Trovafloxacin, a new fluoroquinolone, produced bactericidal activity (-0.33 +/- 0.13 delta log10 CFU/ml.h; intravenously [i.v.] administered dose, 15 mg/kg) comparable to that of vancomycin (-0.39 +/- 0.18 delta log10 CFU/ml.h; i.v. admininistered dose, 20 mg/kg) in the treatment of experimental meningitis in rabbits due to a pneumococcal strain highly resistant to penicillin (MIC of penicillin G, 4 micrograms/ml). The combination of both drugs significantly increased (P < 0.05) the killing rate (-0.60 +/- 0.23 delta log10 CFU/ml.h) compared to that produced by either monotherapy. These results were also confirmed in vitro. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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