Nitrogen dioxide formation during inhaled nitric oxide therapy.
| Autor: | Sokol GM; Department of Pediatrics, Indiana University, Indianapolis, IN 46202, USA.gsokol@iupui.edu, Van Meurs KP, Wright LL, Rivera O, Thorn WJ 3rd, Chu PM, Sams RL |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Clinical chemistry [Clin Chem] 1999 Mar; Vol. 45 (3), pp. 382-7. |
| Abstrakt: | Background: Nitrogen dioxide (NO2) is a toxic by-product of inhalation therapy with nitric oxide (NO). The rate of NO2 formation during NO therapy is controversial. Methods: The formation of NO2 was studied under dynamic flows emulating a base case NO ventilator mixture containing 80 ppm NO in a 90% oxygen matrix. The difficulty in measuring NO2 concentrations below 2 ppm accurately was overcome by the use of tunable diode laser absorption spectroscopy. Results: Using a second-order model, the rate constant, k, for NO2 formation was determined to be (1.19 +/- 0.11) x 10(-11) ppm-2s-1, which is in basic agreement with evaluated data from atmospheric literature. Conclusions: Inhaled NO can be delivered safely in a well-designed, continuous flow neonatal ventilatory circuit, and NO2 formation can be calculated reliably using the rate constant and circuit dwell time. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|