| Autor: |
Wihlborg C; Department of Haematology and Infectious Diseases, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden., Sjöberg J, Intaglietta M, Axdorph U, Pisa EK, Pisa P |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of haematology [Br J Haematol] 1999 Feb; Vol. 104 (2), pp. 346-9. |
| DOI: |
10.1046/j.1365-2141.1999.01176.x |
| Abstrakt: |
Regulation of cytokine levels has been shown to be under genetic control through the coding and promoter sequences of genetic polymorphisms. We elucidated the prevalence of a previously described G to A transition polymorphism at position -308 of the tumour necrosis factor-alpha (TNF-alpha) promoter region in a population of patients with Hodgkin's disease (HD) (n = 36) and chronic lymphocytic leukaemia (CLL) (n = 49) and healthy volunteers (n = 51). The DNA fragment containing this polymorphism was amplified by PCR and sequenced by solid-phase minisequencing. The frequency of the TNF-alpha promoter polymorphism was not significantly different between CLL patients and HD patients compared to controls. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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