| Autor: |
Hoekstra A; Department of Bio-Medical Technology, Advanced R&D Cordis Europa NV, Roden, The Netherlands. AHOEKSTR@crdnl.jnj.com, de Langen CD, Nikkels PG, Korteling BJ, Bel KJ, Crijns HJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing [J Interv Card Electrophysiol] 1998 Dec; Vol. 2 (4), pp. 383-9. |
| DOI: |
10.1023/a:1009777024597 |
| Abstrakt: |
A prototype steerable 8.5 F bipolar catheter fitted with a feedback thermocouple was tested in 7 anaesthetized pigs (30 kg) guided by the electrocardiogram in order to modify the AV nodal and His-Purkinje system conductive properties. Thermal energy was delivered by a pressurized N2O tank (> 650 psi) via a cardiac cryo unit (Spembly, Hampshire, UK) into the catheter wherein gas expands resulting in a tip temperature as low as -70 +/- 2 degrees C within 10 seconds. Cryoablation under fluoroscopic and electrocardiographic guidance was applied at distinct sites in both ventricles for 60 or 120 seconds. After a follow-up period of 6 weeks, the ablation lesions found were well demarcated with small margins of hypertrophy of myocardial cells. With respect to lesion volume variability (8-207 mm3) and geometry, a relationship between the 0 degree C isothermic period and cryolesion volume was found. Results of an in vitro model corroborated this relationship. Therefore, an isothermic period probably can predict the lesion size and its geometry in terms of lesion depth. This potential therapeutic mode of transcatheter cryoablation deserves further investigation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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