Autor:	Kubová, M.
Další autoři:	Bohuslav, T. Mareš, Pavel, 1937-
Jazyk:	angličtina
Předmět:	fyziologie člověka human physiology články journal articles epileptické záchvaty klonazepam epileptic seizures GABAergic system clonazepam pierotoxin convusions
Druh dokumentu:	Non-fiction
ISSN:	0862-8408
Abstrakt:	Abstract: The convulsant effects of four doses of picrotoxin (PX)-2, 3, 4, and 6 mg/kg s.c.-were evaluated in the first part of the study. The 4-mg/kg dose, which elicited minimal seizures in all animals, generalized tonic-clonic (major) seizures in 75% of rats and fatal outcome in 69% of rats, was chosen for the second part, i.e. for testing the anticonvulsant action of clonazepam (Rivotril Roche, 0.1 or 1 mg/kg i.p.). Clonazepam exhibited a dose-dependent action against PX-induced seizures, being more efficient against major than against minimal seizures.
Databáze:	Katalog Knihovny AV ČR
Externí odkaz:	Plný text