Effect of stobadine on indomethacin- and ethanol-induced stomach lesions and gastric secretion.

Autor:	Mirossay, Ladislav
Další autoři:	Kohút, Anton, 1940-
Jazyk:	angličtina
Předmět:	fyziologie člověka ethanol krysa obecná human physiology Rattus rattus články journal articles stobadin žaludeční vředy stobadine indomethacin gastric ulcers
Druh dokumentu:	Non-fiction
ISSN:	0862-8408
Abstrakt:	Abstract: Stobadine was found to inhibit the ulcerogenic activity of indomethacin in relation to the dose but was ineffective against the direct necrotizing action of ethanol. It also inhibited gastric acid secretion when administered intraduodenally. Although stobadine is considered to be a scavenger of free radicals, our results indicate that, under the given experimental conditions, it is rather the inhibition of gastric acid secretion that is responsible for its antiulcerogenic effect. The preliminary results do not allow the exclusion of other mechanisms for explaining its antiulcerogenic effect.
Databáze:	Katalog Knihovny AV ČR
Externí odkaz:	Plný text