Observations on the biological activity of epitestosterone.

Autor:	Stárka, Luboslav, 1930-2022
Další autoři:	Hampl, Richard, 1941- Bičíková, Marie Jelínek, Richard, 1934-2008 Doskočil, Milan, 1928-2002
Jazyk:	angličtina
Předmět:	fyziologie člověka human physiology články journal articles embryotoxicita epitestosteron antiandrogenní aktivita inhibice 5α-reduktázy vazba receptoru embryotoxicity epitestosterone antiandrogenic activity 5α-reductase inhibition receptor binding
Druh dokumentu:	Non-fiction
ISSN:	0862-8408
Abstrakt:	Abstract: Epitestosterone, a 17a-epimer of testosterone is a normal constituent of body fluids in many species including man. It has long been believed that it is devoid of any biological significance. However, it is now demonstrated that in in vivo experiments on castrated male mice it counteracts the action of testosterone on androgen-dependent organs. In vitro experiments show that on the overall antiandr 'genicity of epitestosterone participate true antiandrogenic action due to the binding to androgen receptors, strong 5a-reductase inhibiting activity as well as a weak antigonadotropic activity. Epitestosterone is devoid of any embryotoxicity as checked by chick embryo-toxicity screening test.
Databáze:	Katalog Knihovny AV ČR
Externí odkaz:	Plný text