Impaired post-irradiation survival of cyclooxygenase-2-deficient mice.

Autor:	Hofer, Michal
Další autoři:	Hoferová, Zuzana Gruzdev, A. Dušek, L. Falk, Martin, 1976-
Jazyk:	angličtina
Předmět:	ionizující záření ionizing radiation články journal articles cyclooxygenase-2 COX-2 knock-out mice post-irradiation survival post-irradiation inflammation
Druh dokumentu:	Non-fiction
ISSN:	0862-8408
Abstrakt:	Abstract: We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of γ-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, in comparisons with their wild-type counterparts. These findings were related to the previous observations concerning the detrimental influence of the COX-2 genetic disruption on hematopoiesis in sublethally irradiated mice. Deteriorated postirradiation survival of COX-2 KO mice confirmed the previously anticipated conclusion regarding negative influence of the antiinflammatory action of COX-2 deficiency under the conditions of exposure of the animals to ionizing radiation.
Databáze:	Katalog Knihovny AV ČR
Externí odkaz:	Plný text